The VASCEPA® difference.

Treatment options.


When it comes to treating various medical conditions, there are different treatment options.

PRESCRIPTION MEDICATIONS

are clinically proven and FDA- approved to treat medical conditions. They follow strict manufacturing and regulatory standards, are only prescribed by a doctor and are purchased at a pharmacy.

OTC TREATMENTS

over-the-counter treatments are FDA-regulated and found at retail, but do not require a prescription. Examples include headache, cold and allergy medications. There are no OTC triglyceride-lowering medications.

DIETARY SUPPLEMENTS

such as common fish oils and Omega-3s are not FDA-approved. It's important to know that they are not intended nor proven safe or effective to treat patients with medical conditions such as very high triglycerides.

It’s important to understand the differences before treating a medical condition.

VASCEPA is the first and only prescription EPA treatment approved by the FDA to lower very high triglycerides.

Learn why prescription VASCEPA is the clear choice.

DIFFERENCE FROM PRESCRIPTIONS
DIFFERENCE FROM SUPPLEMENTS

VASCEPA is different than other prescription medications.


Earlier generation, FDA-approved treatment options for very high triglycerides are associated with potential unwanted side effects, including muscle pain and a significant increase in bad cholesterol (LDL-C). There's only one VASCEPA.

VASCEPA, along with diet, is clinically proven to
lower very high triglycerides by 33%
in adults without raising bad cholesterol (LDL-C).*
And has a safety profile similar to placebo.

*In MARINE trial, on average, along with diet changes, adults with very high triglycerides experienced a 33% reduction without raising LDL-C vs. placebo. Individual results may vary.

VASCEPA (icosapent ethyl)
is different from
Omega-3-acid ethyl esters.


This chart contains FDA-approved prescription product information related to patients with very high triglycerides taking 4 grams per day.

No head-to-head trials have been conducted between VASCEPA and other prescription Omega-3s.

VASCEPA1
(icosapent ethyl)
Omega-3-acid ethyl esters2-7
Clinically proven and FDA-approved to lower very high triglycerides1-2 Check Mark Check Mark
Contains only one active ingredient:
prescription EPA1
Check Mark
Not shown to raise bad cholesterol (LDL-C)1-2 Check Mark
Doesn't require additional monitoring of bad cholesterol1 Check Mark
No reported "burping, upset stomach, or a change in sense of taste"1-7 Check Mark

Omega-3-acid ethyl esters should not be substituted for VASCEPA.
If your pharmacist suggests switching, talk with your doctor first.

  1. VASCEPA [package insert]. Bedminster, NJ: Amarin Pharma, Inc; 2017.
  2. Omega-3-acid ethyl esters Prescribing Information, GlaxoSmithKline; 2015.
  3. Omega-3 acid ethyl esters Prescribing Information. Amneal Pharmaceuticals of New York LLC; 2016.
  1. Omega-3 acid ethyl esters Prescribing Information. Apotex Inc; 2014.
  2. Omega-3 acid ethyl esters Prescribing Information. Par Pharmaceutical Inc; 2017.
  3. Omega-3 acid ethyl esters Prescribing Information. Strides Pharma Global Pte Ltd; 2017.
  4. Omega-3 acid ethyl esters Prescribing Information. Teva Pharmaceuticals; 2016.

History of other available FDA-approved drug therapies for patients with very high triglycerides.


Fenofibrates and nicotinic acid are two other classes of drug therapy used to treat patients with very high triglyceride levels. Examples of fenofibrates are: TriCor8 and Trilipix9. Examples of nicotinic acid are: Niacor10 and Niaspan11.

These earlier generation classes of triglyceride lowering therapies, initially launched in 1970s and 1950s, respectively, are not recommended by the FDA for use with statin therapy.

Use of fenofibrates, when used to treat patients with very high triglycerides, resulted in increased bad cholesterol levels in many patients.8,9

Read more

Potential adverse side effects of fenofibrates include potential increased muscle pain and increased risk of gallstones.8,9 Potential adverse side effects of nicotinic acid-class drugs include potential increased muscle pain and flushing.10,11

No head-to-head studies have been conducted to compare the effects of VASCEPA to these other therapies.

The information above regarding VASCEPA, Lovaza, fenofibrates and nicotinic acid therapies is from the FDA-approved labels for these drugs. Label comparisons can be misleading based on numerous factors, including different time frames and baseline lipid levels and diets of patients enrolled in the underlying studies of each therapy. For example:

• Higher baseline levels of triglyceride levels often result in greater percentage reduction in triglyceride levels when treated and baseline triglyceride levels were generally higher in studies of very high triglyceride patients for Lovaza and fenofibrates.8-11

• Registration studies for Lovaza, fenofibrates and nicotinic acid therapies in patients with very high triglycerides were conducted in the 1990s or earlier with none of the patients in the studies on statin therapy. Had the baseline triglyceride levels been impacted by statin therapy, the results may have been different.8-11

Potential adverse side effects of fenofibrates include potential increased muscle pain and increased risk of gallstones.8,9 Potential adverse side effects of nicotinic acid-class drugs include potential increased muscle pain and flushing.10,11

No head-to-head studies have been conducted to compare the effects of VASCEPA to these other therapies.

The information above regarding VASCEPA, Lovaza, fenofibrates and nicotinic acid therapies is from the FDA approved labels for these drugs. Label comparisons can be misleading based on numerous factors, including different timeframes and baseline lipid levels and diets of patients enrolled in the underlying studies of each therapy. For example:

• Higher baseline levels of triglyceride levels often result in greater percentage reduction in triglyceride levels when treated and baseline triglyceride levels were generally higher in studies of very high triglyceride patients for Lovaza and fenofibrates.8-11

• Registration studies for Lovaza, fenofibrates and nicotinic acid therapies in patients with very high triglycerides were conducted in the 1990s or earlier with none of the patients in the studies on statin therapy. Had the baseline triglyceride levels been impacted by statin therapy, the results may have been different.8-11

• Higher baseline levels of triglyceride levels often result in greater percentage reduction in triglyceride levels when treated and baseline triglyceride levels were generally higher in studies of very high triglyceride patients for Lovaza and fenofibrates.8-11

• Registration studies for Lovaza, fenofibrates and nicotinic acid therapies in patients with very high triglycerides were conducted in the 1990s or earlier with none of the patients in the studies on statin therapy. Had the baseline triglyceride levels been impacted by statin therapy, the results may have been different.8-11

Patients should consult with their physicians for further information.

Learn how prescription VASCEPA is different
from Omega-3 supplements.


LEARN HOW

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Save on a prescription now. Commercially insured patients
pay as little as $9
for 90 days.

Subject to eligibility. Restrictions apply.

Get Helpful Questions.


Get helpful questions to ask your doctor. Talking points right at your fingertips.

May not be used to obtain prescription drugs paid for in part by Federal or State Healthcare Programs including Medicare, Medicaid, Medicare Advantage, Medicare Part D, Tricare, and VA. Not for use by VT residents, VT licensed medical professionals, patients under 18, where prohibited by law or patient's insurance plan, or where taxed or restricted. Maximum savings of $80 per month or $240 per 90 day supply. Eligible patients include those who participate in commercial insurance, through a healthcare exchange, or pay cash. Offer good through December 31, 2019.

VASCEPA works differently because it is different.


Make the clear choice.

COMMON
FISH OIL

Most unproven fish oil
supplements contain DHA*,
an Omega-3, which can
raise bad cholesterol (LDL-C).

Not FDA-approved
to treat medical conditions,
including very high triglycerides.

Daily dose
It may take up to 10-40
capsules a day to equal the EPA
in a daily dose of VASCEPA.*

Reported to have fishy taste
or cause fishy burps.*

Prone to deterioration
Fishy smell suggests chemical change and may be covered up by an added scent or flavor.

*Data on file.

Prescription EPA VASCEPA.
No DHA; and VASCEPA
was shown not to raise
bad cholesterol (LDL-C).

FDA-approved
and clinically proven to
lower very high triglycerides.

Daily dose:
Two 1-gram capsules,
twice a day.

No reported fishy taste
or fishy burps taking
4 grams per day of VASCEPA
in a clinical trial.

Proven Stability
Demonstrated multi-year stability [preserves full effect].

§MARINE trial, as compared with placebo.

*Data on file.
MARINE trial, as compared with placebo.

COMMON FISH OIL
VASCEPA

Most unproven fish oil supplements contain DHA, an Omega-3, which can raise bad cholesterol (LDL-C).

Not FDA-approved
to treat medical conditions, including very high triglycerides.

Daily dose It may take up to
10-40 capsules a day
to equal the EPA in a
daily dose of VASCEPA.

Reported to have fishy taste or cause fishy burps.

Data on file.

VASCEPA Pure EPA
Prescription Omega-3.
No DHA; and VASCEPA
was shown not to raise bad cholesterol (LDL-C).§

FDA-approved and clinically proven to lower very high triglycerides.

Daily dose: Two 1-gram capsules,
twice a day.

No reported fishy taste or fishy burps taking 4 grams per day of VASCEPA in a clinical trial.§

§MARINE trial, as compared with placebo.

Prescription
VASCEPA
is different from unproven fish oil supplements.


VASCEPA, along with diet, is the only prescription EPA treatment clinically proven to lower very high triglycerides in adults by 33%, without raising bad cholesterol (LDL-C).

Unlike VASCEPA, common fish oil supplements contain DHA which can raise bad cholesterol.1 They may also contain saturated fats and other ingredients. Fish oil supplements are not intended for high dose use. In fact, the FDA states that supplements should be limited to 3 grams per day.2

Common fish oil supplements are not proven safe or effective to treat patients with medical conditions.

In MARINE trial, on average, along with diet changes, adults with very high triglycerides experienced a 33% reduction without raising LDL-C vs. placebo. Individual results may vary.
1National Lipid Association Recommendations - Part 1, Table 5 and 13, 2015.
2FDA GRAS Notice 2003, page 2, paragraph 6.

Why should you take VASCEPA?


When it comes to lowering very high triglycerides, here are some reasons why VASCEPA is the clear choice.

FDA-Approved VASCEPA

FDA-Approved.

VASCEPA follows strict prescription medication regulatory, consistency and purity standards.

No DHA VASCEPA

One Active Ingredient.

Prescription EPA VASCEPA has only one active ingredient and a safety profile similar to placebo.

Pure EPA Omega-3 VASCEPA

No DHA. No Saturated Fats.

VASCEPA is purified and doesn't contain potentially harmful or unwanted components, impurities or saturated fats.

Power button

Pure Power. Proven to Work.

Unlike unproven fish oil supplements, prescription VASCEPA, along with diet, is clinically proven to lower very high triglycerides in adults by 33%, without raising bad cholesterol.

Cost-effective prescription drug

Greater Coverage and Savings.

With the VASCEPA Savings Card, commercially insured patients pay as little as $9 for 90 days. With the co-pay card, VASCEPA can be significantly less than the cost of unproven fish oil supplements.

VASCEPA vs. Fish Oil

No Fishy Burps.

A clinical study showed that no one taking 4 grams per day of VASCEPA reported a fishy taste or fishy burps.

Learn how VASCEPA is also different from other prescription medications for very high triglycerides.

Compare The Difference

May not be used to obtain prescription drugs paid for in part by Federal or State Healthcare Programs including Medicare, Medicaid, Medicare Advantage, Medicare Part D, Tricare, and VA. Not for use by VT residents, VT licensed medical professionals, patients under 18, where prohibited by law or patient’s insurance plan, or where taxed or restricted. Maximum savings of $80 per month or $240 per 90 day supply. Eligible patients include those who participate in commercial insurance, through a healthcare exchange, or pay cash. Offer good through December 31, 2019.

Dr. Eliot Brinton makes it
clear why prescription VASCEPA matters.


Watch the video
below to learn more.

Video featuring Dr. Eliot Brinton

Paid Medical Expert

Quotation Marks

Dietary supplements are not intended for the treatment of disease.

—Dr. Eliot Brinton,
MD, FAMA, FNLA, President and Director of Utah Lipid Center

Sign Up.


Sign up for the VASCEPA Clear Path Support Program. Recipes, exercises and the latest VASCEPA monthly news - just for you.

Save Now.


Save on a prescription now. Commercially insured patients
pay as little as $9
for 90 days.

Subject to eligibility. Restrictions apply.

Get Helpful Questions.


Get helpful questions to ask your doctor. Talking points right at your fingertips.

May not be used to obtain prescription drugs paid for in part by Federal or State Healthcare Programs including Medicare, Medicaid, Medicare Advantage, Medicare Part D, Tricare, and VA. Not for use by VT residents, VT licensed medical professionals, patients under 18, where prohibited by law or patient's insurance plan, or where taxed or restricted. Maximum savings of $80 per month or $240 per 90 day supply. Eligible patients include those who participate in commercial insurance, through a healthcare exchange, or pay cash. Offer good through December 31, 2019.

 
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INDICATION AND IMPORTANT SAFETY INFORMATION

WHAT IS VASCEPA?

VASCEPA is a prescription medicine used along with a low-fat and low-cholesterol diet to lower high levels of triglycerides (fats) in adults.

  • It is not known if VASCEPA changes your risk of having inflammation of your pancreas (pancreatitis).
  • It is not known if VASCEPA prevents you from having a heart attack or stroke.
  • It is not known if VASCEPA is safe and effective in children.

IMPORTANT SAFETY INFORMATION

WHO SHOULD NOT TAKE VASCEPA?

  • Do not take VASCEPA if you are allergic to icosapent ethyl or any of the ingredients in VASCEPA.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF VASCEPA?

  • It is not known if people who are allergic to fish or shellfish are also allergic to VASCEPA.
  • If you have liver problems and are taking VASCEPA, your doctor should do blood tests during treatment.
  • The most common side effect of VASCEPA is joint pain. Talk to your doctor for medical advice about side effects.

As with all drugs, you may experience a serious side effect when taking VASCEPA.

You may report side effects by calling 1-855-VASCEPA or the FDA at 1-800-FDA-1088.

Tell your doctor if you take medicines that affect your blood clotting (anticoagulants or blood thinners).

Take VASCEPA capsules whole. Do not break, crush, dissolve, or chew VASCEPA capsules before swallowing.

For more information on VASCEPA, click here to see the full Patient Information or call 1-855-VASCEPA (1-855-827-2372).